Kather H, Walter E, Simon B
Fortschr Med. 1978 Sep 14;96(34):1693-6.
The role of the number and size of adipocytes in the pathogenesis of obesity is reviewed. The observation that hyperplasia of adipose tissue is associated with child-onset obesity was over-interpreted. Nevertheless most recent studies suggest that fact cell size and number are regulated and can influence food intake. The discovery of preadipocytes has opened a new field or research offering the possibility of new concepts in the prevention and therapy of obesity.
本文综述了脂肪细胞数量和大小在肥胖发病机制中的作用。脂肪组织增生与儿童期肥胖相关这一观察结果曾被过度解读。然而，最近的大多数研究表明，脂肪细胞的大小和数量是受调控的，并且会影响食物摄入量。前脂肪细胞的发现开辟了一个新的研究领域，为肥胖的预防和治疗提供了新观念的可能性。
