Takagi S, Yoshida T, Ohya A, Tsubata K, Sakata H, Fujii K T, Iizuka S, Tochigi B, Tochigi M, Mochigi A
Prostaglandins. 1982 Apr;23(4):591-601. doi: 10.1016/0090-6980(82)90119-8.
The present clinical trials revealed that 16,16-Dimethyl-trans-delta 2-PGE1 methyl ester in the form of vaginal suppositories is highly effective in inducing mid-trimester termination of pregnancies. It also showed that prior treatment with laminaria and metreurynter may enhance the success rate while reducing the incidence and severity of side effects. It is easy and safe to use clinically, with minimal side effects, and in our series, revealed no deleterious effects on ensuing reproductive physiology. However, the definite mechanism involved in the action of this new analogue to cause myometrial contractions is still not completely understood, and requires further intensive investigation.
目前的临床试验表明，阴道栓剂形式的16,16 - 二甲基 - 反式 - δ2 - PGE1甲酯在诱导中期妊娠终止方面非常有效。研究还表明，术前使用海带棒和宫颈扩张棒可能会提高成功率，同时降低副作用的发生率和严重程度。其临床使用简便、安全，副作用极小，在我们的系列研究中，未发现对后续生殖生理有有害影响。然而，这种新类似物引起子宫肌层收缩的确切作用机制仍未完全明了，需要进一步深入研究。
