Shoenfeld Y, Rothenberg M, Berliner S, Gallant L A, Garfinkel D, Shaklai M, Pinkhas J
Scand J Haematol. 1982 Apr;28(4):335-40. doi: 10.1111/j.1600-0609.1982.tb00535.x.
13 patients with adult non-lymphocytic leukemia (ANLL) who developed central nervous system (CNS) involvement during the course of their illness are reported and compared with a control group of 26 ANLL patients without CNS involvement. The incidence of CNS involvement was 13/510 patients (2.5%). Initial symptoms and signs and routine laboratory data were not helpful in predicting which patients would ultimately develop CNS involvement. Almost 1/2 of the patients were in clinical and haematological remission at the time of the diagnosis of CNS involvement. Specific treatment to the CNS including intrathecal cytotoxic drugs and/or radiotherapy failed to increase the survival rate significantly. Whether the establishment of an early diagnosis of CNS involvement and the institution of appropriate treatment may improve the prognosis of this complication is a question which presently remains unanswered.
报告了13例成年非淋巴细胞白血病（ANLL）患者，他们在病程中出现了中枢神经系统（CNS）受累情况，并与26例无CNS受累的ANLL患者对照组进行了比较。CNS受累的发生率为13/510例患者（2.5%）。初始症状、体征和常规实验室数据无助于预测哪些患者最终会发生CNS受累。几乎1/2的患者在诊断CNS受累时处于临床和血液学缓解状态。针对CNS的特异性治疗，包括鞘内注射细胞毒性药物和/或放疗，未能显著提高生存率。早期诊断CNS受累并采取适当治疗是否能改善这种并发症的预后，这一问题目前仍未得到解答。
