Abbott D, Rotnem D, Genel M, Cohen D J
Schizophr Bull. 1982;8(2):310-9. doi: 10.1093/schbul/8.2.310.
Eleven children with documented growth hormone deficiency were studied to assess their cognitive and emotional functioning and their academic achievement before and after 1 year of human growth hormone replacement therapy. Standardized personality and intelligence measures were used, and records of school achievement, as well as developmental and family history from parents, were obtained. Although some subjects in this group were coping with problems other than their short stature (e.g., other medical and psychosocial problems), their intelligence and academic achievement were found to be positively correlated with socioeconomic status and independent of the condition of hypopituitarism. This study supports others that have found these children vulnerable to problems of emotional adjustment in middle and late childhood. Because of the heterogeneity of the group, findings must be interpreted cautiously. However, the consistent finding of disturbance in visual-motor integration is thought to be significant and demonstrates the need for further research that will examine possible neurological sequelae of long-term growth hormone deficiency.
对11名确诊为生长激素缺乏症的儿童进行了研究，以评估他们在接受1年人生长激素替代治疗前后的认知、情绪功能以及学业成绩。使用了标准化的人格和智力测量方法，并获取了学业成绩记录以及父母提供的发育和家族史。尽管该组中的一些受试者除身材矮小外还应对其他问题（如其他医学和社会心理问题），但发现他们的智力和学业成绩与社会经济地位呈正相关，且与垂体功能减退状况无关。这项研究支持了其他一些研究，这些研究发现这些儿童在童年中期和后期容易出现情绪调整问题。由于该组的异质性，研究结果必须谨慎解释。然而，视觉运动整合障碍的一致发现被认为具有重要意义，并表明需要进一步研究，以检查长期生长激素缺乏可能导致的神经后遗症。
