Fornasier V L, Stapleton K, Williams C C
Hum Pathol. 1978 Jul;9(4):455-61. doi: 10.1016/s0046-8177(78)80030-6.
In recent years the use of calcitonin in the medical treatment of Paget's disease of bone has been gaining in popularity. Seventeen patients on long term calcitonin therapy showed objective morphologic evidence of improvement in the quality of bone matrix deposition, in the trabecular organization, and in the parameters used to evaluate the rates of bone turnover. The usefulness of bone biopsy and fine detail radiography of the biopsy core in evaluating the progress of disease and the effects of therapy is discussed. It is concluded that the longer the period of therapy and follow-up, the higher the proportion of patients showing histologic evidence of improvement.
近年来，降钙素在骨Paget病的医学治疗中的应用越来越普遍。17名接受长期降钙素治疗的患者显示，在骨基质沉积质量、小梁结构以及用于评估骨转换率的参数方面有客观的形态学改善证据。本文讨论了骨活检及活检芯的精细放射摄影在评估疾病进展和治疗效果方面的作用。得出的结论是，治疗和随访时间越长，显示出组织学改善证据的患者比例越高。
