Dion W M, Dukes T W
Sabouraudia. 1982 Jun;20(2):95-100. doi: 10.1080/00362178285380161.
Candida rugosa was isolated from the milk of 70% of the cows in a dairy herd with mastitis problems. An experimental C. rugosa infection of the udder of a healthy cow resulted in a prolonged fever and an inflammatory reaction in the mammary gland and associated lymph nodes. Milk secretion in the 2 infected quarters was reduced from 8.51 to 1.51 per day. Histological examination revealed alveolar destruction with interstitial fibrosis accompanied by lymphocyte and macrophage accumulation. C. rugosa was cultured form the cisternal mammary tissue of the infected quarters but not from the alveolar tissue or associated lymph nodes. There was no evidence of tissue invasion. The signs described were probably due to toxic components in the fungal cell walls combined with the adverse effects of lowered pH in the milk during the proliferation of the yeast.
在一个存在乳腺炎问题的奶牛场中，70%的奶牛乳汁中分离出了皱落假丝酵母。对一头健康奶牛的乳房进行实验性皱落假丝酵母感染，导致了持续发热以及乳腺和相关淋巴结的炎症反应。两个感染乳腺区的乳汁分泌量从每天8.51降至1.51。组织学检查显示肺泡破坏伴间质纤维化，伴有淋巴细胞和巨噬细胞积聚。从感染乳腺区的乳腺池组织中培养出了皱落假丝酵母，但在肺泡组织或相关淋巴结中未培养出。没有组织侵袭的证据。所描述的症状可能是由于真菌细胞壁中的毒性成分，以及酵母增殖过程中牛奶pH值降低的不利影响所致。
