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凝血过程中的脂蛋白组分与抗凝血酶III消耗情况

Lipoprotein fractions and antithrombin III consumption during clotting.

作者信息

Winter J H, Bennett B, McTaggart F, Douglas A S

出版信息

Thromb Haemost. 1982 Jun 28;47(3):236-8.

PMID:7112497
Abstract

Plasma and serum antithrombin levels were measured in functional (initial rate measurement) and immunological assays together with serum lipid levels in normal subjects and patients with coronary artery disease. Specific antithrombin activity in plasma showed a negative correlation with triglyceride levels. The consumption of antithrombin activity during blood clotting was negatively correlated with both serum total triglyceride and heparin precipitable lipoprotein and positively correlated with serum high density lipoprotein cholesterol. Different blood lipoprotein fractions may influence the activity of the antithrombin III molecule.

摘要

在正常受试者和冠心病患者中,采用功能测定法(初始速率测定)和免疫测定法对血浆和血清抗凝血酶水平以及血清脂质水平进行了测量。血浆中的特异性抗凝血酶活性与甘油三酯水平呈负相关。血液凝固过程中抗凝血酶活性的消耗与血清总甘油三酯和肝素可沉淀脂蛋白均呈负相关,与血清高密度脂蛋白胆固醇呈正相关。不同的血液脂蛋白组分可能会影响抗凝血酶III分子的活性。

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