三乙基铅毒性与脑谷胱甘肽及谷胱甘肽S-转移酶的关系
Triethyl lead toxicity in relation to brain glutathione and glutathione S-transferase.
作者信息
Chand P, Clausen J
出版信息
Toxicol Lett. 1982 Jul;12(2-3):181-4. doi: 10.1016/0378-4274(82)90183-7.
PMID:7112612
Abstract
A dose-dependent decrease in the content of reduced glutathione (GSH) was found in the brain of rats following treatment with Pb(Et)3 for varying time intervals. Maximum inhibition of 19% was observed 3 h after the last dose of Pb(Et)3 (8 mg/kg) daily for 3 days. Glutathione S-transferase activity did not change significantly. In vitro, there was no conjugation of GSH with PbEt3 and the addition of brain cytosol did not catalyse the conjugation.
摘要
在用不同时间间隔的三乙基铅（Pb(Et)3）处理大鼠后，发现其大脑中还原型谷胱甘肽（GSH）含量呈剂量依赖性下降。每天给予Pb(Et)3（8毫克/千克），连续3天，末次给药3小时后观察到最大抑制率为19%。谷胱甘肽S-转移酶活性无显著变化。在体外，GSH与三乙基铅（PbEt3）未发生结合，添加脑细胞质也未催化结合反应。
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