Titov V N, Sanfirova V M, Khodakova T D, Kantardzhian I G
Vopr Med Khim. 1982 Jul-Aug;28(4):38-42.
Effect of hydrocortisone on biosynthesis of cholesterol and phospholipids in liver tissue was studied using intact rats, in adrenalectomy, under conditions of stimulation of lipid biosynthesis by cholestyramine and Triton WR-1339. Hydrocortisone was shown to inhibit biosynthesis of cholesterol and phospholipids in rat liver tissue if 2-14C-acetate was used as a precursor. The hormone inhibited biosynthesis of lipid components in membranes of adrenalectomized rats. Under conditions of preactivation of the lipid biosynthesis, using simulation with cholestyramine and Trition WR-1339, hydrocortisone decreased the synthesis of cholesterol and phospholipids.
利用完整大鼠、肾上腺切除大鼠，在消胆胺和曲拉通WR - 1339刺激脂质生物合成的条件下，研究了氢化可的松对肝组织中胆固醇和磷脂生物合成的影响。如果使用2 - 14C - 醋酸盐作为前体，氢化可的松可抑制大鼠肝组织中胆固醇和磷脂的生物合成。该激素抑制肾上腺切除大鼠膜中脂质成分的生物合成。在脂质生物合成预激活的条件下，通过消胆胺和曲拉通WR - 1339模拟，氢化可的松可降低胆固醇和磷脂的合成。
