Lashneva N V
Vopr Pitan. 1982 May-Jun(3):26-9.
Male Wistar rats kept on the iron-deficient diet for 7-71/2 weeks showed an increase in the content of cytochromes P450 and b5 in liver microsomes that was accompanied by the elevated rate of N-demethylation of amidopyrin and dimethylalanine (type I substrates), and by that of p-hydroxylation of aniline (type II substrate). The changes described wee observed in the presence of a 20-25% reduction in the hemoglobin content in the blood of experimental animals. Administration to rats of phenobarbital (100 mg per kg mass daily for 3 days) caused an induction of the monooxygenase system of the liver endoplasmic reticulum. However under the conditions of iron deficiency in the diet the degree of cytochrome P450 induction and that of the reaction rate of N-demethylation in microsomes were slightly less than under the full-value diet.
持续7至7.5周食用缺铁饮食的雄性Wistar大鼠，其肝脏微粒体中细胞色素P450和b5的含量增加，同时氨基比林和二甲基丙氨酸（I型底物）的N-去甲基化速率以及苯胺（II型底物）的对羟基化速率升高。上述变化是在实验动物血液中血红蛋白含量降低20 - 25%的情况下观察到的。给大鼠每日腹腔注射苯巴比妥（每千克体重100毫克，连续3天）可诱导肝脏内质网的单加氧酶系统。然而，在饮食缺铁的情况下，细胞色素P450的诱导程度以及微粒体中N-去甲基化反应速率均略低于正常饮食情况下。
