雌激素替代疗法期间性激素结合球蛋白能力的比较纵向研究。

A comparative longitudinal study on sex hormone binding globulin capacity during estrogen replacement therapy.

作者信息

Helgason S, Damber J E, Damber M G, von Schoultz B, Selstam G, Södergård R

出版信息

Acta Obstet Gynecol Scand. 1982;61(2):97-100. doi: 10.3109/00016348209156536.

DOI:10.3109/00016348209156536

Abstract

An aqueous two-phase equilibrium partition system was used to assay SHBG-binding capacity. Sera from groups of postmenopausal women before and during unopposed estrogen replacement therapy were analyzed. The induction of SHBG showed considerable differences between different estrogens. Ethinyl-estradiol in a daily dose of 0.05 mg gave a 70% increase in the serum concentration of this liver derived protein. Estradiol-17 beta, 2 mg daily and estrone sulphate 1.25 mg gave moderate changes, whereas estriol in different doses had no effect. SHBG induction may reflect estrogen overtreatment.

摘要

采用水相双相平衡分配系统来测定性激素结合球蛋白（SHBG）结合能力。对绝经后妇女在接受单一雌激素替代疗法之前和期间的血清进行了分析。不同雌激素对SHBG的诱导作用存在显著差异。每日剂量为0.05毫克的乙炔雌二醇可使这种肝脏衍生蛋白的血清浓度增加70%。每日2毫克的17β-雌二醇和1.25毫克的硫酸雌酮引起的变化适中，而不同剂量的雌三醇则没有效果。SHBG的诱导可能反映了雌激素的过度治疗。