Loukovaara M, Carson M, Adlercreutz H
Department of Clinical Chemistry, University of Helsinki, Meilahti Hospital, Finland.
Biochem Biophys Res Commun. 1995 Jan 26;206(3):895-901. doi: 10.1006/bbrc.1995.1127.
The effect of endogenous estrogens on sex-hormone-binding globulin (SHBG) production was studied in HepG2 cells. 17 beta-estradiol, estrone, and estrogens from both 2- and 16 alpha-hydroxylative pathways stimulated SHBG production, but not in parallel with their binding affinities for the estrogen receptor. Thus, the underlying mechanism may be other than a pure interaction with the estrogen receptor.
