Shiota K
Am J Med Genet. 1982 Jul;12(3):281-8. doi: 10.1002/ajmg.1320120306.
A causal relationship between neural tube defects and maternal febrile illness in early pregnancy was investigated retrospectively using human embryo data from Japan. The frequency of febrile illness was compared with corresponding data from normal controls, and holoprosencephalic and polydactylous embryos. Within the group of neural tube defects, the prevalence of maternal hyperthermia was significantly higher than in normal control and holoprosencephaly mothers. The association was constant and highly significant specifically for exencephaly, which is an embryonic forerunner of anencephaly. The correlation with myeloschisis (without exencephaly) was not significant. In eight out of the ten cases in which the timing of the fever was known, it occurred during the clinically determined critical period of neural tube closure in human embryos. These results support the hypothesis that maternal hyperthermia in early pregnancy can cause neural tube defects in man, especially anencephaly.
利用来自日本的人类胚胎数据，对神经管缺陷与孕早期母体发热性疾病之间的因果关系进行了回顾性研究。将发热性疾病的发生率与正常对照、前脑无裂畸形和多指畸形胚胎的相应数据进行了比较。在神经管缺陷组中，母体体温过高的发生率显著高于正常对照和前脑无裂畸形母亲。这种关联是持续的，并且对于无脑儿的胚胎先兆——露脑畸形而言具有高度显著性。与脊柱裂（无脑畸形除外）的相关性不显著。在已知发热时间的10例病例中，有8例发生在临床确定的人类胚胎神经管闭合关键期。这些结果支持了这样的假说，即孕早期母体体温过高可导致人类神经管缺陷，尤其是无脑儿。
