Heubi J E, Fondacaro J D
Am J Physiol. 1982 Sep;243(3):G189-94. doi: 10.1152/ajpgi.1982.243.3.G189.
The postnatal development of intestinal bile salt transport was examined in the guinea pig. Using an in vitro technique, mucosal uptake of taurocholate was measured in jejunum and ileum at five monomeric concentrations from fetal, 1-day-old, 5-day-old, 10-day-old, 21-day-old, and adult animals. Jejunal taurocholate uptake was linear with respect to concentration and was not inhibited by taurochenodeoxycholate at all ages studied. In fetal and 1-day-old animals, ileal taurocholate uptake was linear and was not inhibited by taurochenodeoxycholate. A curvilinear relation between uptake and taurocholate concentration, which was inhibited by taurochenodeoxycholate, was observed in 5-day-old and older animals. These findings indicate that, in the guinea pig, passive diffusion of taurocholate is the only mode of intestinal transport in fetuses and newborns and the sole mode of jejunal transport at all ages. By 5 days, however, active ileal transport appears, which persists into adulthood and contributes to the development of an efficient enterohepatic circulation of bile salts.
在豚鼠中研究了肠道胆盐转运的产后发育情况。采用体外技术，在来自胎儿、1日龄、5日龄、10日龄、21日龄和成年动物的空肠和回肠中，于五种单体浓度下测量牛磺胆酸盐的黏膜摄取。空肠中牛磺胆酸盐的摄取与浓度呈线性关系，并且在所有研究的年龄段均不受牛磺鹅去氧胆酸盐的抑制。在胎儿和1日龄动物中，回肠牛磺胆酸盐的摄取呈线性，且不受牛磺鹅去氧胆酸盐的抑制。在5日龄及以上的动物中，观察到摄取与牛磺胆酸盐浓度之间呈曲线关系，且该关系受牛磺鹅去氧胆酸盐抑制。这些发现表明，在豚鼠中，牛磺胆酸盐的被动扩散是胎儿和新生儿肠道转运的唯一模式，也是所有年龄段空肠转运的唯一模式。然而，到5日龄时，回肠的主动转运出现，这种转运持续到成年，并有助于高效的胆盐肠肝循环的发育。
