Levine D P, Cushing R D, Jui J, Brown W J
Ann Intern Med. 1982 Sep;97(3):330-8. doi: 10.7326/0003-4819-97-3-330.
Between June 1980 and September 1981 we evaluated 24 cases of endocarditis from methicillin-resistant Staphylococcus aureus. All of the cases occurred in drug addicts and all were community-acquired. The patients ranged in age from 21 to 59 years and represented an older population than that generally reported for bacterial endocarditis in addicts. Men and women were equally represented (one man presented twice). This unusually high proportion of women may reflect a difference in the rate and location of carriage of methicillin-resistant S. aureus compared with that of methicillin-sensitive staphylococci. Three patients died, one of whom had signed out of the hospital on the 14th day and returned moribund 27 days later. Vancomycin treatment for 28 days was adequate therapy for most patients.
1980年6月至1981年9月期间，我们评估了24例耐甲氧西林金黄色葡萄球菌引起的心内膜炎病例。所有病例均发生在吸毒者中，且均为社区获得性感染。患者年龄在21岁至59岁之间，比一般报道的吸毒者细菌性心内膜炎患者群体年龄更大。男女比例相当（有一名男性出现了两次）。女性比例异常之高，可能反映出耐甲氧西林金黄色葡萄球菌与甲氧西林敏感葡萄球菌在携带率和携带部位上存在差异。3例患者死亡，其中1例在第14天出院，27天后奄奄一息地返回。对大多数患者而言，28天的万古霉素治疗是足够的疗法。
