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耐万古霉素肠球菌耐药性的调控：VanRS双组分系统

Regulation of Resistance in Vancomycin-Resistant Enterococci: The VanRS Two-Component System.

作者信息

Guffey Alexandra A, Loll Patrick J

机构信息

Department of Biochemistry & Molecular Biology, College of Medicine, Drexel University, Philadelphia, PA 19102, USA.

出版信息

Microorganisms. 2021 Sep 25;9(10):2026. doi: 10.3390/microorganisms9102026.

DOI:10.3390/microorganisms9102026
PMID:34683347
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8541618/
Abstract

Vancomycin-resistant enterococci (VRE) are a serious threat to human health, with few treatment options being available. New therapeutics are urgently needed to relieve the health and economic burdens presented by VRE. A potential target for new therapeutics is the VanRS two-component system, which regulates the expression of vancomycin resistance in VRE. VanS is a sensor histidine kinase that detects vancomycin and in turn activates VanR; VanR is a response regulator that, when activated, directs expression of vancomycin-resistance genes. This review of VanRS examines how the expression of vancomycin resistance is regulated, and provides an update on one of the field's most pressing questions: How does VanS sense vancomycin?

摘要

耐万古霉素肠球菌（VRE）对人类健康构成严重威胁，可供选择的治疗方法很少。迫切需要新的治疗方法来减轻VRE带来的健康和经济负担。新治疗方法的一个潜在靶点是VanRS双组分系统，该系统调节VRE中万古霉素抗性的表达。VanS是一种传感组氨酸激酶，可检测万古霉素并进而激活VanR；VanR是一种反应调节因子，激活后可指导万古霉素抗性基因的表达。本文对VanRS进行综述，探讨万古霉素抗性的表达是如何调控的，并就该领域最紧迫的问题之一提供最新信息：VanS如何感知万古霉素？

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05aa/8541618/e2d130e00a6c/microorganisms-09-02026-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05aa/8541618/8ffe25550285/microorganisms-09-02026-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05aa/8541618/0ab9be0b2e84/microorganisms-09-02026-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05aa/8541618/48bc28f01ad6/microorganisms-09-02026-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05aa/8541618/b470351289a7/microorganisms-09-02026-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05aa/8541618/3bd7c7a44df3/microorganisms-09-02026-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05aa/8541618/e2d130e00a6c/microorganisms-09-02026-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05aa/8541618/8ffe25550285/microorganisms-09-02026-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05aa/8541618/0ab9be0b2e84/microorganisms-09-02026-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05aa/8541618/48bc28f01ad6/microorganisms-09-02026-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05aa/8541618/b470351289a7/microorganisms-09-02026-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05aa/8541618/3bd7c7a44df3/microorganisms-09-02026-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/05aa/8541618/e2d130e00a6c/microorganisms-09-02026-g005.jpg

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