Nelson W H, Orr W W, Stevenson J M, Shane S R
Arch Gen Psychiatry. 1982 Sep;39(9):1033-6. doi: 10.1001/archpsyc.1982.04290090031007.
Hypothalamic-pituitary-adrenal (HPA) axis activity was studied in 28 endogenously depressed, hospitalized patients. Measures of HPA activity obtained were baseline serum cortisol level, 24-hour urinary free cortisol excretion, and an overnight 2-mg dexamethasone suppression test. The patients then received double-blind and randomized treatment with imipramine hydrochloride, 150 mg daily, or amitriptyline hydrochloride, 150 mg daily, for four weeks. Four-week treatment response of all patients was compared with pretreatment HPA axis variables, and higher cortisol values after dexamethasone administration were found to be significantly correlated with greater improvement. There were no significant differences between imipramine and amitriptyline response, however, when improvement with each drug was compared with the pretreatment HPA variables.
对28名内源性抑郁症住院患者的下丘脑-垂体-肾上腺（HPA）轴活性进行了研究。所获得的HPA活性指标包括基线血清皮质醇水平、24小时尿游离皮质醇排泄量以及过夜2毫克地塞米松抑制试验。然后，患者接受为期四周的双盲随机治疗，每日服用150毫克盐酸丙咪嗪或150毫克盐酸阿米替林。将所有患者的四周治疗反应与治疗前的HPA轴变量进行比较，发现地塞米松给药后较高的皮质醇值与更大程度的改善显著相关。然而，当将每种药物的改善情况与治疗前的HPA变量进行比较时，丙咪嗪和阿米替林的反应没有显著差异。
