Schaupp H, Wohnaut H
HNO. 1978 Oct;26(10):335-41.
Oral disinfectants containing chlorhexidine or hexetidine are able to produce disturbances of taste, as demonstrated by Krarup's electrogustometric method and the gustometric method of Harris and Kalmus. Hypo- and dysgeusia are characterized by dissociated disturbances, the most prominent of which concerns the sweet perception. The bitter taste is least affected, whereas the effects on salty and acidic tastes range between that for sweet and bitter. Taste disturbances which include ageusia for 48 h were observed when the tongue was touched with a 20% solution of chlorhexidine. Not only the disinfectants themselves provoked dysgeusia but also other "taste improving" agents (particularly, the volatile oild). In addition to dysgeusia, the authors found disturbances of the mucous membrane sensitivity caused by the test substances.
含有洗必泰或己脒定的口腔消毒剂能够产生味觉障碍，这已通过克拉鲁普的电味觉测量法以及哈里斯和卡尔穆斯的味觉测量法得到证实。味觉减退和味觉障碍的特征是分离性障碍，其中最突出的是甜味感知方面的问题。苦味受影响最小，而对咸味和酸味的影响则介于甜味和苦味之间。当用20%的洗必泰溶液接触舌头时，观察到味觉障碍包括48小时的味觉缺失。不仅消毒剂本身会引发味觉障碍，其他“改善味觉”的制剂（特别是挥发油）也会如此。除了味觉障碍，作者还发现测试物质会引起黏膜敏感性障碍。
