Coker N J, Milner P F
Arch Otolaryngol. 1982 Sep;108(9):574-6. doi: 10.1001/archotol.1982.00790570040010.
Between July 1977 and October 1981, nine patients with sickle cell anemia underwent tonsillectomy or tonsillectomy with adenoidectomy without operative or postoperative morbidity or mortality. Appropriate management is necessary to prevent vaso-occlusive events. The current protocol for elective surgery used at the Medical College of Georgia, Augusta, consists of the following: (1) preoperative transfusion and hydration, (2) intraoperative prevention of hypothermia and maintenance of blood volume, and (3) postoperative oxygen therapy and hydration. The critical requirement of this protocol is the preoperative transfusion of these patients with packed cells consisting of hemoglobin A erythrocytes to lower the percentage of Hb S to less than 45% as determined by quantitative hemoglobin electrophoresis.
1977年7月至1981年10月期间，9例镰状细胞贫血患者接受了扁桃体切除术或扁桃体切除术加腺样体切除术，术中及术后均无发病或死亡情况。采取适当的处理措施对于预防血管闭塞事件很有必要。佐治亚医学院奥古斯塔分校目前用于择期手术的方案如下：（1）术前输血及补液；（2）术中预防体温过低并维持血容量；（3）术后氧疗及补液。该方案的关键要求是术前给这些患者输注由血红蛋白A红细胞组成的浓缩红细胞，以使经定量血红蛋白电泳测定的Hb S百分比降至45%以下。
