Schatte C L, Mathias M M
Aviat Space Environ Med. 1982 Jul;53(7):629-32.
Weanling male rats were fed a semi-purified diet containing 10, 20, 40 or 60% of calories as fat having a constant polyunsaturated/saturated fatty acid ratio of 0.7. After 21-28 d of feeding, animals from each treatment group were exposed to pure oxygen at one atmosphere absolute for up to 72 h. Some animals were sacrificed after 0 or 48 h of oxygen exposure and lung tissue analyzed for the activities of the hexose monophosphate shunt and prostaglandin dehydrogenase/reductase. Other animals were exposed to hyperoxia until death. With increasing dietary fat content, the pre-exposure activities of the two enzymes decreased and oxygen-induced mortality increased. There was no dietary effect on enzyme activities after 48 h of hyperoxia. We concluded that both dietary fat content and the pre-exposure activity of prostaglandin dehydrogenase/reductase influenced the relative susceptibility to pulmonary oxygen poisoning.
将断奶雄性大鼠喂食一种半纯化饮食，该饮食含有占热量10%、20%、40%或60%的脂肪，其多不饱和/饱和脂肪酸比例恒定为0.7。喂食21 - 28天后，每个处理组的动物在1个绝对大气压下暴露于纯氧中长达72小时。一些动物在暴露于氧气0小时或48小时后处死，对肺组织进行分析以检测磷酸己糖旁路和前列腺素脱氢酶/还原酶的活性。其他动物暴露于高氧环境直至死亡。随着饮食中脂肪含量的增加，两种酶的暴露前活性降低，氧气诱导的死亡率增加。高氧暴露48小时后，饮食对酶活性没有影响。我们得出结论，饮食脂肪含量和前列腺素脱氢酶/还原酶的暴露前活性均影响对肺氧中毒的相对易感性。
