Adams C W, Miller N E, Morgan R S, Rao S N
Atherosclerosis. 1982 Jul;44(1):1-8. doi: 10.1016/0021-9150(82)90047-8.
A group of 12 young NZW rabbits of the same breeding strain were fed a diet enriched with 0.1% cholesterol by weight. The resulting modest hypercholesterolaemia resolved after 4-5 months. Two animals that died during this period showed no gross or microscopic atherosclerosis. After 6 months, the dietary cholesterol was increased to 0.2%. In some animals this resulted in moderate hypercholesterolaemia. One animal that died at this time showed no atherosclerosis with a mean serum cholesterol level of 224 mg/dl. Just after one year, dietary cholesterol was increased to 0.3%. This resulted in definite hypercholesterolaemia in some animals, but a few resisted the treatment with mean serum cholesterol levels around 40-60 mg/dl. In general, animals with established hypercholesterolaemia showed severe atherosclerosis, but often of a more fibrous and less cellular nature than is usual in the rabbit. Aortic wall cholesterol content (on a weight basis) correlated positively with serum cholesterol concentration (r = + 0.69, P approximately 0.05) and negatively with the ratio of HDL cholesterol to (LDL plus VLDL) cholesterol (double log plot: r = -0.79, P less than 0.025).
一组12只相同繁殖品系的年轻新西兰白兔被喂食了按重量计富含0.1%胆固醇的饮食。由此产生的轻度高胆固醇血症在4至5个月后消退。在此期间死亡的两只动物未表现出明显的或微观的动脉粥样硬化。6个月后，饮食中的胆固醇增加到0.2%。在一些动物中这导致了中度高胆固醇血症。此时死亡的一只动物未表现出动脉粥样硬化，其平均血清胆固醇水平为224毫克/分升。刚好在一年后，饮食中的胆固醇增加到0.3%。这在一些动物中导致了明确的高胆固醇血症，但有几只动物抵抗了这种治疗，其平均血清胆固醇水平在40至60毫克/分升左右。一般来说，已患高胆固醇血症的动物表现出严重的动脉粥样硬化，但通常比兔子中常见的情况更具纤维性且细胞性更低。主动脉壁胆固醇含量（按重量计算）与血清胆固醇浓度呈正相关（r = +0.69，P约为0.05），与高密度脂蛋白胆固醇与（低密度脂蛋白加极低密度脂蛋白）胆固醇的比率呈负相关（双对数图：r = -0.79，P小于0.025）。
