Blagoeva P M, Balanski R M
Biull Eksp Biol Med. 1982 Jun;93(6):88-9.
In cytosol of normal and tumor tissues obtained from rats and hamsters, antiradical activity (ARA) of bioantioxidants was assayed by the method of Glavind, while the content of sulfhydryl groups by the method of Ellman. ARA of normal tissues (liver, kidneys, stomach, large intestine, femoral muscles) was lower than the content of free SH-groups. The difference between the magnitudes under consideration was always negative in all the test tissues. In tumors of the liver, stomach, kidneys, large intestine and femoral muscle induced in rats and hamsters by chemical carcinogens, there was an increase in ARA from 21 to 125.8% as compared with respective normal tissues. The difference between ARA and the content of SH-groups in the tumors was always positive. It might be assumed that in normal tissues, ARA is primarily determined by sulfhydryl compounds. Meanwhile, apart from SH-containing compounds, the other substances also take part in the control of ARA.
在从大鼠和仓鼠获取的正常组织及肿瘤组织的胞质溶胶中，生物抗氧化剂的抗自由基活性（ARA）采用格拉温德法进行测定，而巯基含量则采用埃尔曼法测定。正常组织（肝脏、肾脏、胃、大肠、股肌）的ARA低于游离巯基的含量。在所研究的所有测试组织中，所考虑的这两个量值之间的差异始终为负。在大鼠和仓鼠经化学致癌物诱导产生的肝脏、胃、肾脏、大肠及股肌肿瘤中，与各自的正常组织相比，ARA增加了21%至125.8%。肿瘤中ARA与巯基含量之间的差异始终为正。可以假定，在正常组织中，ARA主要由巯基化合物决定。同时，除了含巯基化合物外，其他物质也参与了对ARA的调控。
