Freedman B, Richmond D R, Kelly D T
Circulation. 1982 Oct;66(4):705-9. doi: 10.1161/01.cir.66.4.705.
Coronary arterial measurements were made from cineangiograms in patients with positive and negative ergonovine tests. In those with positive tests, normal segments of arteries adjacent to the site of spasm and arteries without spasm showed no greater sensitivity to ergonovine than arteries from control patients (20 +/- 13% constriction vs 17 +/- 12%, NS). In patients with positive and negative ergonovine tests, constriction was measured at lesion sites after ergonovine and compared with values predicted from a geometric theory. The measured constriction was always greater than predicted in patients with a positive ergonovine test, and frequently less than predicted in patients with a negative test. The increased sensitivity of arteries that show localized vasospasm at lesion sites after ergonovine administration is not explained by geometry alone.
对麦角新碱试验阳性和阴性的患者进行冠状动脉造影测量。在试验阳性的患者中，与痉挛部位相邻的动脉正常节段以及未发生痉挛的动脉对麦角新碱的敏感性并不高于对照患者的动脉（收缩率为20±13%对17±12%，无显著性差异）。在麦角新碱试验阳性和阴性的患者中，在给予麦角新碱后测量病变部位的收缩情况，并与根据几何理论预测的值进行比较。在麦角新碱试验阳性的患者中，测量到的收缩总是大于预测值，而在试验阴性的患者中则常常小于预测值。麦角新碱给药后在病变部位出现局部血管痉挛的动脉敏感性增加，这不能仅用几何学来解释。
