人类失活X染色体的复制变体。I. 单个个体淋巴细胞内的变异性。
Replication variants of the human inactive X chromosome. I. Variability within lymphocytes of single individuals.
作者信息
Schmidt M, Stolzmann W M, Baranovskaya L I
出版信息
Chromosoma. 1982;85(3):405-12. doi: 10.1007/BF00330363.
PMID:7117031
Abstract
The sequence of DNA replication was studied within the inactive X chromosome in human lymphocytes, by means of the FPG method. Several variants of the replication sequence were found. The number of variants in the cells of a single donor exceeded 2 in each of the 4 normal individuals studied. The phenomenon is discussed with respect to the regulation of DNA synthesis and to the cell differentiation process.
摘要
采用FPG方法研究了人类淋巴细胞中失活X染色体内DNA复制的序列。发现了复制序列的几种变体。在所研究的4名正常个体中，每个个体单个供体细胞中的变体数量均超过2种。就DNA合成的调控和细胞分化过程对该现象进行了讨论。
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