硅橡胶毛细管中的氧交换。

Oxygen exchange in silicone rubber capillaries.

作者信息

Heineken F G, Predecki P K, Filley G F

出版信息

J Bioeng. 1978 Jun;2(3-4):195-204.

Abstract

Capillaries of 7 and 12.5 mu diameter have been fabricated in silicone rubber. Whole blood treated with heparin has been perfused through these capillaries. Under flowing conditions, no clotting or other clumping effects have been observed and red cells appear to maintain a constant velocity. Oxygen transfer data to and from saline perfusing the 12.5 mu diameter capillaries have been obtained in order to determine how rapidly O2 will permeate the silicone rubber film. The data indicate that the capillaries simulate lung tissue oxygen exchange and will allow for the first time the experimental determination of oxygen exchange kinetics in flowing whole blood.

摘要

已在硅橡胶中制造出直径为7微米和12.5微米的毛细血管。用肝素处理过的全血已通过这些毛细血管进行灌注。在流动条件下，未观察到凝血或其他结块效应，红细胞似乎保持恒定速度。已获取了与灌注直径为12.5微米毛细血管的盐水之间的氧气传输数据，以确定氧气透过硅橡胶膜的速度有多快。数据表明，这些毛细血管模拟了肺组织的氧气交换，并将首次允许对流动全血中的氧气交换动力学进行实验测定。