Chuang L W, Karoum F, Wyatt R J
Eur J Pharmacol. 1982 Jul 16;81(3):385-92. doi: 10.1016/0014-2999(82)90103-0.
The effects of acute semichronic (twice daily for three days) treatments with the same doses of amphetamine (AMPH) and methamphetamine (M-AMPH) on rat brain phenylethylamine (PEA) and catecholamines were evaluated. These treatments produced similar behavioral responses and hence are assumed to be generally equipotent. Both drugs entered the brain rapidly but at different rates. While AMPH and M-AMPH produced comparable changes in the contents of catecholamines and their metabolites in the hypothalamus and caudate nucleus, only AMPH significantly elevated PEA. The elevated brain PEA produced by AMPH was not due to alpha-demethylation of AMPH. It is concluded that brain PEA may mediate some of AMPH behavioral effects but not those of M-AMPH. The catecholamines appear to be involved in the effects of both drugs.
评估了相同剂量的苯丙胺（AMPH）和甲基苯丙胺（M-AMPH）急性半慢性（连续三天每天两次）处理对大鼠脑苯乙胺（PEA）和儿茶酚胺的影响。这些处理产生了相似的行为反应，因此被认为一般具有等效效力。两种药物都能迅速进入大脑，但速率不同。虽然AMPH和M-AMPH在下丘脑和尾状核中儿茶酚胺及其代谢物的含量上产生了相当的变化，但只有AMPH显著提高了PEA。AMPH引起的脑PEA升高并非由于AMPH的α-去甲基化。结论是脑PEA可能介导了AMPH的一些行为效应，但不是M-AMPH的行为效应。儿茶酚胺似乎参与了两种药物的效应。
