Holohean A M, White F J, Appel J B
Eur J Pharmacol. 1982 Jul 30;81(4):595-602. doi: 10.1016/0014-2999(82)90349-1.
The involvement of dopamine (DA) and serotonin (5-HT) neuronal systems in the discriminative stimulus effects of various ergot derivatives was assessed by administering four ergots to 36 rats which had been trained to discriminate either apomorphine (APO) or d-lysergic acid diethylamide (LSD) from saline. Lergotrile, lisuride and LSD substituted for APO (0.25 mg/kg) while bromocriptine and ergonovine (ergometrine) did not; only lisuride mimicked LSD (0.08 mg/kg). Antagonism tests showed that the DA antagonist haloperidol but not the 5-HT antagonist BC-105 (pizotifen) blocked the APO cue; both the LSD cue and the substitution of LSD for APO were blocked by BC-105 but not by haloperidol. It was concluded that DA receptor activation plays a prominent role in the discriminative stimulus effects of lergotrile and lisuride as well as APO and a secondary role in the LSD cue; 5-HT seems to be of major importance in the mediation of the effects of LSD and, to a lesser extent, lisuride. The functions of the two monoamines in the discriminable effects of bromocriptine and, particularly, ergonovine are less clear.
通过给36只已训练从盐水中辨别出阿扑吗啡（APO）或d - 麦角酸二乙酰胺（LSD）的大鼠施用四种麦角生物碱，评估多巴胺（DA）和5 - 羟色胺（5 - HT）神经元系统在各种麦角衍生物辨别刺激效应中的作用。麦角腈、利苏瑞和LSD可替代APO（0.25毫克/千克），而溴隐亭和麦角新碱（麦角胺）则不能；只有利苏瑞能模拟LSD（0.08毫克/千克）。拮抗试验表明，DA拮抗剂氟哌啶醇而非5 - HT拮抗剂BC - 105（匹莫齐特）能阻断APO提示；BC - 105而非氟哌啶醇能阻断LSD提示以及LSD替代APO的情况。得出的结论是，DA受体激活在麦角腈、利苏瑞以及APO的辨别刺激效应中起主要作用，在LSD提示中起次要作用；5 - HT似乎在LSD以及程度较轻的利苏瑞的效应介导中起主要作用。两种单胺在溴隐亭尤其是麦角新碱的可辨别效应中的功能尚不清楚。
