[胆固醇合成抑制剂对Wistar和Sprague-Dawley大鼠的致畸作用]
[Teratogenic action of an inhibitor of cholesterol synthesis in Wistar and Sprague-Dawley rats].
作者信息
Roux C, Horvath H, Dupuis R, Aubry M M
出版信息
C R Seances Soc Biol Fil. 1977;171(1):15-9.
PMID:71186
Abstract
Sprague-Dawley rats are sensitive to the teratogenic action of AY 9944, an inhibitor of cholesterol synthesis, but the dose of inhibitor necessary to induce the same rate of characteristic malformations is twice as large for Sprague-Dawley as for Wistar rats. This variation is probably related to differences in levels of blood cholesterol in the strains and demonstrates a relationship between teratogenicity and metabolic disturbances.
摘要
斯普拉格-道利大鼠对胆固醇合成抑制剂AY 9944的致畸作用敏感，但诱导相同特征性畸形发生率所需的抑制剂剂量，斯普拉格-道利大鼠是Wistar大鼠的两倍。这种差异可能与品系中血液胆固醇水平的差异有关，并表明致畸性与代谢紊乱之间存在关联。
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[Teratogenic action of an inhibitor of cholesterol synthesis in Wistar and Sprague-Dawley rats].[胆固醇合成抑制剂对Wistar和Sprague-Dawley大鼠的致畸作用]
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