Hayashi M, Nagasaka T, Shibata H
J Appl Physiol Respir Environ Exerc Physiol. 1982 Jul;53(1):117-20. doi: 10.1152/jappl.1982.53.1.117.
Wistar rats fasted for 48 h were exposed to hypoxia (9.5% O2 in N2) at ambient temperatures (Ta) of 13.5, 24.5, and 32.0 degrees C. In normoxic environment, fasted rats showed significantly lower values of oxygen consumption (VO2), dry heat loss (R + C + K), and colonic temperature (Tcol) than in fed counterparts. The extent of decrease in each parameter was nearly same at any Ta. On exposure to hypoxia, fed rats showed a significant decrease in VO2, (R + C + K), and Tcol at any Ta. The decrease was particularly great at Ta 13.5 degrees C. In contrast to fed rats, fasted rats showed a significant decrease in all of these parameters only at Ta 13.5 degrees C. No such decrease was observed at Ta 24.5 and 32.0 degrees C. However, a significant difference in Tcol was found at Ta 24.5 degrees C in fasted rats between normoxic and hypoxic environments. Moreover, there was no statistically significant difference between fed and fasted rats in each parameter at any Ta in hypoxia. These results suggest that hypoxia suppresses both dietary-induced and cold-induced components of metabolism in rats.
将禁食48小时的Wistar大鼠在环境温度（Ta）为13.5、24.5和32.0摄氏度的条件下暴露于低氧环境（氮气中9.5%的氧气）。在常氧环境中，禁食大鼠的耗氧量（VO2）、干热损失（R + C + K）和结肠温度（Tcol）值显著低于进食大鼠。在任何Ta下，每个参数的下降程度几乎相同。暴露于低氧环境时，进食大鼠在任何Ta下的VO2、（R + C + K）和Tcol均显著下降。在Ta 13.5摄氏度时下降尤为明显。与进食大鼠不同，禁食大鼠仅在Ta 13.5摄氏度时所有这些参数均显著下降。在Ta 24.5和32.0摄氏度时未观察到这种下降。然而，在Ta 24.5摄氏度时，禁食大鼠在常氧和低氧环境之间的Tcol存在显著差异。此外，在低氧环境下，任何Ta时进食和禁食大鼠在每个参数上均无统计学显著差异。这些结果表明，低氧抑制了大鼠饮食诱导和寒冷诱导的代谢成分。
