奇异变形杆菌青霉素G酰化酶受三羧酸循环中间产物的抑制作用。
Repression of penicillin G acylase of Proteus rettgeri by tricarboxylic acid cycle intermediates.
作者信息
Daumy G O, McColl A S, Apostolakos D
出版信息
J Bacteriol. 1982 Oct;152(1):104-10. doi: 10.1128/jb.152.1.104-110.1982.
Abstract
The regulation of the penicillin acylase in proteus rettgeri ATCC 31052 was compared with that of the enzyme in Escherichia coli ATCC 9637. Unlike the E. coli acylase, the P. rettgeri enzyme was not induced by phenylacetic acid, nor was it subject to catabolite repression by glucose. The P. rettgeri acylase appears to be expressed constitutively but is subject to repression by the C4-dicarboxylic acids of the tricarboxylic acid cycle, succinate, fumarate, and malate.
摘要
对雷特格变形杆菌ATCC 31052中青霉素酰化酶的调控与大肠杆菌ATCC 9637中该酶的调控进行了比较。与大肠杆菌酰化酶不同，雷特格变形杆菌的酶不受苯乙酸诱导，也不受葡萄糖的分解代谢物阻遏。雷特格变形杆菌酰化酶似乎是组成型表达，但受到三羧酸循环中的C4-二羧酸（琥珀酸、富马酸和苹果酸）的阻遏。
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