毒扁豆碱和新斯的明对豚鼠离体心房的变力性和变时性作用。

The inotropic and chronotropic effects of physostigmine and neostigmine on guinea-pig isolated atria.

作者信息

De Wildt D J, Oud P H, Porsius A J

出版信息

J Auton Pharmacol. 1982 Jun;2(2):111-7. doi: 10.1111/j.1474-8673.1982.tb00476.x.

DOI:10.1111/j.1474-8673.1982.tb00476.x

Abstract

1 Physostigmine (0.1-1 mM) induced dose-dependent negative and neostigmine (0.1-1 mM) positive inotropic effects on driven guinea-pig isolated atria. Physostigmine decreased and neostigmine increased cardiac frequency of spontaneously beating atria. 2 The depression of amplitude of contraction by physostigmine cannot be attributed to its inhibitory effect on tissue cholinesterase. The negative inotropic action of physostigmine is not influenced by preincubation with atropine. 3 The positive inotropic effect of neostigmine is not caused by a nicotine-like action of the drug. Neostigmine (1 mM) counteracts the negative inotropic effect of acetylcholine. The possible mechanisms of action are discussed.

摘要

1 毒扁豆碱（0.1 - 1 mM）对豚鼠离体心房产生剂量依赖性负性变力作用，新斯的明（0.1 - 1 mM）则产生正性变力作用。毒扁豆碱降低、新斯的明增加自发搏动心房的心率。2 毒扁豆碱对收缩幅度的抑制作用不能归因于其对组织胆碱酯酶的抑制效应。毒扁豆碱的负性变力作用不受与阿托品预孵育的影响。3 新斯的明的正性变力作用并非由该药物的烟碱样作用引起。新斯的明（1 mM）可对抗乙酰胆碱的负性变力作用。文中讨论了可能的作用机制。