Artru A A, Michenfelder J D
J Neurochem. 1982 Oct;39(4):1198-200. doi: 10.1111/j.1471-4159.1982.tb11517.x.
Dietary cyclocreatine has been reported to increase brain high-energy stores in mice and to prolong the generation and utilization of these stores following decapitation. A possible cerebral protective action after 50 days of dietary cyclocreatine 0.5 and 1.0% was therefore examined in mice. Cyclocreatine 0.5% did not increase survival time during hypoxia (5% O2). Cyclocreatine 1.0% in the absence of hypoxia caused significant mortality and decreased weight in survivors despite prophylactic antibiotic treatment. Dietary cyclocreatine offers no cerebral protection against hypoxia in mice.
据报道，膳食中的环肌酸可增加小鼠大脑中的高能储备，并在断头后延长这些储备的产生和利用时间。因此，研究了在小鼠中给予0.5%和1.0%的膳食环肌酸50天后可能的脑保护作用。0.5%的环肌酸并未增加缺氧（5%氧气）期间的存活时间。在无缺氧情况下，1.0%的环肌酸尽管进行了预防性抗生素治疗，但仍导致显著死亡率，并使存活者体重下降。膳食环肌酸对小鼠缺氧没有脑保护作用。
