吡哆醇缺乏大鼠胆固醇代谢的刺激作用

Stimulation of cholesterol metabolism in pyridoxine-deficient rats.

作者信息

Iwami T, Okada M

出版信息

J Nutr Sci Vitaminol (Tokyo). 1982 Apr;28(2):77-84. doi: 10.3177/jnsv.28.77.

DOI:10.3177/jnsv.28.77

Abstract

The effect of pyridoxine deficiency on cholesterol catabolism was studied in rats. The concentrations of bile lipid components were higher in pyridoxine-deficient rats than in controls. A decreased ratio of taurine to glycine conjugates was observed in the deficient rats. No change in the neutral sterol content, but an increase in the bile acid content of the feces was observed in the deficient rats. Increased cholesterol catabolism in pyridoxine-deficient rats was also shown by the shorter half-life of the [14C] cholesterol injected into these animals.

摘要

在大鼠中研究了维生素B6缺乏对胆固醇分解代谢的影响。维生素B6缺乏的大鼠胆汁脂质成分浓度高于对照组。在缺乏维生素B6的大鼠中观察到牛磺酸与甘氨酸结合物的比例降低。在缺乏维生素B6的大鼠中，粪便中性固醇含量没有变化，但胆汁酸含量增加。给这些动物注射的[14C]胆固醇半衰期缩短，也表明维生素B6缺乏的大鼠胆固醇分解代谢增加。

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