Guerrero J, Page M R, Schad G A
J Parasitol. 1982 Aug;68(4):616-9.
The efficacy and minimum therapeutic dose of closantel, an injectable salicylanilide anthelmintic, was evaluated on adult Ancylostoma caninum. Doses of 7.5 and 10 mg/kg had a marked anthelmintic effect on adult stages, removing 99 and 98%, respectively. A second experiment tested the efficacy of closantel against hypobiotic larval stages of A. caninum. A dose of 20 mg/kg did not affect the abundance of arrested hookworm larvae or prevent their subsequent development, but it may have inhibited their full maturation as adult worms so that patent, intestinal infections did not occur. Small numbers of adults were recovered from treated dogs at 29, 43, and 57 days post-treatment, but no eggs were passed in their feces. These studies bear on the practical problem of control of hookworms in dogs.
对一种可注射的水杨酰苯胺驱虫药氯氰碘柳胺的疗效和最小治疗剂量进行了评估，受试对象为成年犬钩虫。7.5毫克/千克和10毫克/千克的剂量对成虫阶段有显著驱虫效果，分别清除了99%和98%的成虫。第二项实验测试了氯氰碘柳胺对犬钩虫休眠幼虫阶段的疗效。20毫克/千克的剂量并未影响滞育钩虫幼虫的数量，也未阻止其随后发育，但可能抑制了它们发育为成虫的完全成熟过程，因此未发生明显的肠道感染。在治疗后第29天、43天和57天，从接受治疗的犬只体内发现少量成虫，但它们的粪便中未排出虫卵。这些研究与犬钩虫控制的实际问题相关。
