Kurabuchi S, Inoue S
J Morphol. 1982 Aug;173(2):129-35. doi: 10.1002/jmor.1051730202.
The regenerative capacity of limbs was investigated by amputation of limbs at the zeugopodium in postmetamorphic froglets and adults of various sizes in four species of Japanese frogs, all of which showed some regeneration at these ages. In Hyla arborea japonica and Rana brevipoda porosa most young froglets regenerated their limbs well; however, the rate of regeneration decreased with the age of amputation, and the limb became nonregenerative in adults. Limbs of adults in Rana rugosa and R. japonica, on the other hand, exhibited good regeneration. All of the regenerates in the four species were heteromorphic, consisting histologically of well-developed cartilaginous rods surrounded by connective tissue and skin. Limited development of muscle was apparent in regenerates of the three ranid species. The relations between body size, innervation of limbs, and regenerative capacity are discussed.
通过对四种日本蛙不同大小的变态后幼蛙和成蛙的四肢在zeugopodium处进行截肢，研究了四肢的再生能力，所有这些蛙在这些年龄段都表现出一定程度的再生。在日本树蛙和多疣狭口蛙中，大多数幼蛙四肢再生良好；然而，再生率随着截肢时年龄的增长而降低，成年蛙的四肢不再具有再生能力。另一方面，皱皮蛙和日本林蛙成年蛙的四肢表现出良好的再生能力。这四个物种的所有再生肢体都是异形的，组织学上由结缔组织和皮肤包围的发育良好的软骨棒组成。在三种蛙科物种的再生肢体中，肌肉发育有限。文中讨论了体型、四肢神经支配和再生能力之间的关系。
