Roberts J A, Fischman N H, Thomas R
J Urol. 1982 Sep;128(3):650-2. doi: 10.1016/s0022-5347(17)53086-4.
It has been said that vesicoureteral reflux causes renal scarring because of intrarenal reflux. We studied reflux in the monkey because of its similarity to man, especially in regard to the incidence of vesicoureteral reflux and chronic pyelonephritis. High pressure moderate grade reflux was produced and renal function followed by means of quantitative renal camera studies using 131I hippuran. There was no change in renal function from sterile reflux even when intrarenal reflux occurred. When, however, infection was introduced, renal function decreased. We concluded that sterile moderate vesicoureteral or intrarenal reflux does not harm the kidney.
据说膀胱输尿管反流会因肾内反流而导致肾瘢痕形成。由于猴子与人类相似，尤其是在膀胱输尿管反流和慢性肾盂肾炎的发病率方面，我们对其进行了反流研究。通过使用131I马尿酸进行定量肾显像研究，产生了高压中度反流并对肾功能进行了跟踪。即使发生肾内反流，无菌反流也不会导致肾功能改变。然而，当引入感染时，肾功能会下降。我们得出结论，无菌的中度膀胱输尿管反流或肾内反流不会损害肾脏。
