Rovagnati P, di Padova C, di Padova F, Munari L, Tritapepe R
Methods Find Exp Clin Pharmacol. 1982;4(5):313-6.
The administration of large doses (5 mg/kg b.wt./day) of ethynylestradiol to adult female hamsters did not induce cholestasis or modifications of bile lipid composition. These findings are in contrast with the data of other authors who in different experimental conditions described the sensitivity of hamsters to the estrogen-induced hepatobiliary toxicity. Ascorbic acid alone or added to ethynylestradiol did not impair bile secretion. However, it significantly increased the plasma levels of radioactivity tested 24 hours after the oral administration of a tracer dose of radiolabelled ethynylestradiol. These results confirm previous data showing in humans the capability of ascorbic acid to favour the rise of plasma concentrations of ethynylestradiol.
给成年雌性仓鼠大剂量（5毫克/千克体重/天）乙炔雌二醇并未引起胆汁淤积或胆汁脂质成分的改变。这些发现与其他作者的数据相反，其他作者在不同实验条件下描述了仓鼠对雌激素诱导的肝胆毒性的敏感性。单独使用抗坏血酸或添加到乙炔雌二醇中均未损害胆汁分泌。然而，在口服示踪剂量的放射性标记乙炔雌二醇24小时后进行检测，抗坏血酸显著提高了血浆放射性水平。这些结果证实了先前的数据，即在人类中抗坏血酸能够促进乙炔雌二醇血浆浓度的升高。
