Guslandi M
Methods Find Exp Clin Pharmacol. 1982;4(5):317-20.
Of the various mechanisms proposed to explain the cytoprotective properties of prostaglandins, mucus discharge seems the most probable. Mild irritants capable of eliciting mucus release have also been shown to exert cytoprotection. It is suggested that prostaglandins act as mild irritants of the mucosa and that cytoprotection is a mucosal reaction to mild irritation, through stimulation of mucus discharge.
在为解释前列腺素的细胞保护特性而提出的各种机制中,黏液分泌似乎是最有可能的。能够引发黏液释放的轻度刺激物也已被证明具有细胞保护作用。有人提出,前列腺素作为黏膜的轻度刺激物,而细胞保护作用是黏膜对轻度刺激的反应,是通过刺激黏液分泌实现的。