Prokof'eva-Bel'govskaia A A
Mol Biol (Mosk). 1982 Jul-Aug;16(4):771-81.
The functional relationship between the transformations of chromosome structure and parallel changes of its major components, i. e. DNA, histones and non-histone proteins (NHP) has been analysed. These changes of chromosome have been checked in the early development, in the highly differentiated undividing cells, in the mitotic and meiotic cells, till the gamete formation. The analysis performed enable us to propose that chromosomal non-histone proteins play the main role in the transformation of chromosome structure, decreasing its genetic activity. NHPs aged without renewal in the undivided nuclei and chromosomes. These proteins take part in the formation of synaptonemal complex (SC) in the early meiotic prophase during chromosome pairing; SC is subsequently eliminated in the diplotene. Thus mature sperms and eggs are characterized by NHP deficiency. NHPs are synthesized de novo in the chromosomes after fertilization providing genetic function of the chromosomes in the development and differentiation of cell systems in new generation of organisms.
已经分析了染色体结构变化与其主要成分（即DNA、组蛋白和非组蛋白（NHP））的平行变化之间的功能关系。这些染色体变化已在早期发育、高度分化的不分裂细胞、有丝分裂和减数分裂细胞中进行了检查，直至配子形成。所进行的分析使我们能够提出，染色体非组蛋白在染色体结构转化中起主要作用，降低其遗传活性。NHP在不分裂的细胞核和染色体中老化且无更新。这些蛋白质在减数分裂前期早期染色体配对过程中参与联会复合体（SC）的形成；SC随后在双线期消失。因此，成熟精子和卵子的特征是NHP缺乏。受精后，NHP在染色体中重新合成，为新一代生物体细胞系统发育和分化过程中染色体的遗传功能提供支持。
