Albrecht-Buehler G
Natl Cancer Inst Monogr. 1982;60:117-22.
The cytoplasm of migrating animal cells appears to be composed of smaller, autonomously moving units (microplasts). Consequently, the mere act of displacement of a cell calls for the existence of communicating the strategy-issuing cell centers to guarantee cooperation between the autonomous parts. These centers appear to control cell migration in that they "steer" two sister cells along symmetrical or identical pathways. They lead a cell out of the collision with another at the same angle at which they collided and seem to communicate with control centers of other cells because cells can migrate directionally as groups. They even seem to collect spatial data as demonstrated by cells which followed a guiding line and arrived at the intersection between two such lines. There the cells appeared to probe all optional directions before choosing one. Thus the concept emerges that tissue cells are active data collecting and processing organisms. As a further consequence, the question has to be asked seriously whether aging the cancer, both of which appear to involve behavioral defects of cells, are related to reprogrammed control centers of cell movement.
正在迁移的动物细胞的细胞质似乎由较小的、自主移动的单元（微质体）组成。因此，细胞的简单位移行为需要存在向发出策略的细胞中心进行通信，以保证自主部分之间的协作。这些中心似乎控制着细胞迁移，因为它们“引导”两个姐妹细胞沿着对称或相同的路径移动。它们以与碰撞相同的角度引导一个细胞避开与另一个细胞的碰撞，并且似乎与其他细胞的控制中心进行通信，因为细胞可以成群地定向迁移。它们甚至似乎会收集空间数据，就像沿着引导线移动并到达两条这样的线的交点的细胞所证明的那样。在那里，细胞似乎会在选择一个方向之前探测所有可选方向。因此，出现了这样一个概念，即组织细胞是活跃的数据收集和处理生物体。进一步的结果是，必须严肃地提出这样一个问题，即衰老和癌症，这两者似乎都涉及细胞的行为缺陷，是否与细胞运动的重新编程控制中心有关。
