D'Mello G D
Neuropharmacology. 1982 Aug;21(8):763-9. doi: 10.1016/0028-3908(82)90062-4.
Rats were trained to discriminate d-amphetamine (1.0 mg/kg) or clonidine (0.06 mg/kg) from saline in a standard, two-lever procedure with food reinforcement (n = 6). The similarity between the discriminable properties of amphetamine and clonidine was both partial and asymmetrical. Cross tests with amylobarbitone and chlordiazepoxide in rats trained with clonidine suggested that a major component of the clonidine stimulus may be general sedation. Pretreatment with the alpha 2-adrenoreceptor antagonist, piperoxane partially antagonized the discriminative stimulus produced by clonidine. The alpha 1 antagonist, phenoxybenzamine failed to alter the clonidine stimulus. Although amphetamine and clonidine may share some elements in common, this may not represent a noradrenergic component in the amphetamine discriminative stimulus since noradrenergic mediation of the clonidine stimulus was not established.
采用标准的双杠杆程序，以食物强化训练大鼠区分右旋苯丙胺（1.0毫克/千克）或可乐定（0.06毫克/千克）与生理盐水（n = 6）。苯丙胺和可乐定可区分特性之间的相似性是部分的且不对称。在用可乐定训练的大鼠中用戊巴比妥和氯氮卓进行交叉测试表明，可乐定刺激的一个主要成分可能是全身镇静作用。用α2-肾上腺素能受体拮抗剂哌罗克生预处理可部分拮抗可乐定产生的辨别性刺激。α1拮抗剂酚苄明未能改变可乐定刺激。虽然苯丙胺和可乐定可能有一些共同元素，但这可能并不代表苯丙胺辨别性刺激中的去甲肾上腺素能成分，因为可乐定刺激的去甲肾上腺素能介导尚未确定。
