Kucera P, de Ribaupierre Y
Prog Clin Biol Res. 1982;85 Pt B:433-44.
The changes of viscosity in different regions of the intact living early chick embryo were recorded by a new sensitive and non-invasive technique. In the heart, the very first yet invisible mechanical activity has been clearly detected and its further differentiation followed. In other regions, especially in the Hensen's node, spontaneous slow and oscillating mechanical activity has been observed. It has been shown that the undifferentiated embryonic tissue can as well respond to electrical, mechanical or chemical stimulations. The recorded changes have been interpreted as manifestations of the cell mechanical work i.e. active tension, cell shaping or movement. The technique represents a new tool for physiological and pharmacological studies of the undifferentiated embryonic cells and the early morphogenetic phenomena.
通过一种新的灵敏且非侵入性技术记录了完整存活的早期鸡胚不同区域的粘度变化。在心脏中，首次清晰检测到了极其微弱且不可见的机械活动，并追踪了其进一步的分化过程。在其他区域，尤其是亨氏结，观察到了自发的缓慢且振荡的机械活动。研究表明，未分化的胚胎组织也能对电、机械或化学刺激做出反应。记录到的变化被解释为细胞机械功的表现，即主动张力、细胞塑形或运动。该技术为未分化胚胎细胞和早期形态发生现象的生理学和药理学研究提供了一种新工具。
