Thomas C E, Bell P D, Navar L G
Ren Physiol. 1982;5(4):197-205. doi: 10.1159/000172858.
Although it is recognized that vasodilator-induced increases in renal plasma flow are not associated with increases in glomerular filtration rate (GFR), the mechanism responsible for the failure of GFR to exhibit plasma flow dependency under these circumstances remains uncertain. To evaluate this problem further, the effects of intra-arterial infusion of two vasodilators, bradykinin (n = 7) and papaverine (n = 6), on renal hemodynamics and glomerular function of dogs were determined. Both agents increased renal blood flow; however, GFR and single nephron GFR (SNGFR) remained unchanged during bradykinin infusion and decreased significantly during papaverine infusion. Transglomerular hydrostatic pressure and mean effective filtration pressure were not altered during bradykinin infusion but were significantly reduced by papaverine. Neither agent altered the glomerular filtration coefficient. These observations indicate that, in the dog, the GFR responses during renal vasodilation are dependent primarily on the effective filtration pressure.
尽管人们认识到血管扩张剂引起的肾血浆流量增加与肾小球滤过率（GFR）增加无关，但在这些情况下，GFR未能表现出对血浆流量的依赖性的机制仍不确定。为了进一步评估这个问题，测定了动脉内输注两种血管扩张剂——缓激肽（n = 7）和罂粟碱（n = 6）对犬肾血流动力学和肾小球功能的影响。两种药物均增加了肾血流量；然而，在输注缓激肽期间，GFR和单个肾单位GFR（SNGFR）保持不变，而在输注罂粟碱期间则显著降低。在输注缓激肽期间，跨肾小球静水压力和平均有效滤过压未改变，但罂粟碱使其显著降低。两种药物均未改变肾小球滤过系数。这些观察结果表明，在犬中，肾血管舒张期间的GFR反应主要取决于有效滤过压。
