小鼠行为异常的关键时期。
Critical periods for behavioral anomalies in mice.
作者信息
Rodier P M
出版信息
Environ Health Perspect. 1976 Dec;18:79-83. doi: 10.1289/ehp.761879.
Abstract
While mice have been used less frequently than rats in behavioral research, there use has some advantages in teratological studies. The development of the mouse CNS has been investigated more extensively than that of the rat. Since time of insult has been found to be an important factor in effects on both anatomy and behavior, data on the sequence of events in CNS development are valuable in planning and interpreting behavioral assessments of potential teratogens. A comparison of studies in mice and rats suggests that behavioral effects of teratogens are similar in the two species and demonstrates that mice can be used successfully in a variety of behavioral evaluations.
摘要
虽然在行为研究中，小鼠的使用频率低于大鼠，但在致畸学研究中，使用小鼠有一些优势。对小鼠中枢神经系统发育的研究比对大鼠的研究更为广泛。由于已发现损伤时间是影响解剖结构和行为的重要因素，因此中枢神经系统发育过程中事件序列的数据对于规划和解释潜在致畸剂的行为评估很有价值。对小鼠和大鼠研究的比较表明，致畸剂对这两个物种的行为影响相似，并表明小鼠可成功用于各种行为评估。
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