Breslow R
Science. 1982 Nov 5;218(4572):532-7. doi: 10.1126/science.7123255.
Simple chemical catalysts have been designed to achieve some desirable features of enzymes. These novel catalysts are not proteins, but they may incorporate the typical enzyme catalytic groups and they achieve selectivity in their reactions by use of geometric control, as do enzymes. Catalysts that carry out geometrically controlled chlorinations of aromatic rings and steroids have been constructed. Other catalysts achieve the selective synthesis of amino acids, and still others imitate ribonuclease in detailed mechanism and hydrolyze RNA. Optimization of geometries has led to a rate acceleration of over 10(8) in one instance.
简单的化学催化剂已被设计出来以实现酶的一些理想特性。这些新型催化剂不是蛋白质，但它们可能包含典型的酶催化基团，并且像酶一样通过几何控制在反应中实现选择性。已经构建了能够对芳香环和类固醇进行几何控制氯化反应的催化剂。其他催化剂实现了氨基酸的选择性合成，还有一些在详细机制上模仿核糖核酸酶并水解RNA。在一个实例中，几何结构的优化使反应速率加速超过10的8次方。
