Treatment and follow-up study of squamous cell carcinoma in situ of the cervix uteri.

The survey of approved cancer programs done by the Commission on Cancer of the American College of Surgeons observed a total of 9,468 patients with a diagnosis of in situ squamous cell carcinoma of the cervix uteri. Sixty-four per cent of these patients had been observed for at least nine years. The most commonly used definitive treatment was hysterectomy. Recurrences were observed after hysterectomy, conization and radiation therapy. There were significantly more recurrences in the group treated by conization compared with those treated by hysterectomy. The highest rate of second cancer primary to the vagina, vulva, uterus or ovaries was among patients who received no treatment. The cancer specific, ten year survival rate for those with no treatment was 96.6 per cent, and for those treated by conization or by hysterectomy, the rates were 99.3 and 99.8 per cent, respectively.