Bijlsma J W, Duursma S A, Bosch R, Huber O
Acta Endocrinol (Copenh). 1982 Sep;101(1):140-3. doi: 10.1530/acta.0.1010140.
Eleven male patients with rheumatoid arthritis were treated with the anabolic steroid nandrolondecanoate and parameters of calcium and bone metabolism were studied. No changes were found in the concentrations of calcium, phosphorus or hydroxyproline in serum and urine (corrected for the creaturia). A significant decrease (P less than 0.01) was observed in the levels of alkaline phosphatase, but this was attributed to a change in liver enzymes, because the gamma glutamyl transpeptidase fell. Acid phosphatase levels showed an increase, possibly as a result of an effect of nandrolondecanoate on the prostate. No change was found during treatment in the serum levels of parathyroid hormone, calcitonin, 25 hydroxyvitamin D, 24, 25 dihydroxyvitamin D and 1.25 dihydroxyvitamin D. A seasonal fluctuation was observed for 25 hydroxyvitamin D and 24, 25 dihydroxyvitamin D, but not for 1,25 dihydroxyvitamin D. It was concluded that short-term treatment with the anabolic steroid nandrolondecanoate did not result in changes in parameters of calcium and bone metabolism.
对11名类风湿性关节炎男性患者使用合成代谢类固醇癸酸诺龙进行治疗，并研究了钙和骨代谢参数。血清和尿液中钙、磷或羟脯氨酸的浓度（校正肌酐尿后）未发现变化。碱性磷酸酶水平显著降低（P<0.01），但这归因于肝酶的变化，因为γ-谷氨酰转肽酶下降。酸性磷酸酶水平升高，可能是癸酸诺龙对前列腺产生作用的结果。治疗期间，甲状旁腺激素、降钙素、25-羟维生素D、24,25-二羟维生素D和1,25-二羟维生素D的血清水平未发现变化。观察到25-羟维生素D和24,25-二羟维生素D有季节性波动，但1,25-二羟维生素D没有。得出的结论是，短期使用合成代谢类固醇癸酸诺龙治疗不会导致钙和骨代谢参数发生变化。
