Mitchell A A, Lovejoy F H, Slone D, Shapiro S
Am J Dis Child. 1982 Nov;136(11):976-9. doi: 10.1001/archpedi.1982.03970470020005.
Among 3,587 hospitalized children monitored by the Pediatric Drug Surveillance Program between 1974 and 1979, acetaminophen was prescribed for 32% and aspirin for 3%. In the three months before admission, 23% reported use of either drug. In both inpatient and preadmission settings, acetaminophen use increased between 1975 and 1977 and decreased subsequently. Aspirin prescriptions were consistent over the entire study period among inpatients, but preadmission use decreased substantially. The Massachusetts Poison Information Center observed a 36% increase in calls concerning aspirin from 1976 to 1977 and 1977 to 1978, similar to the increase in all calls, but acetaminophen calls increased by 87%. Long-standing concerns about the toxic effects of aspirin, coupled with recent concerns about hepatotoxic effects of acetaminophen in overdose, may be leading physicians and parents to decrease the use of both drugs for the treatment of fever.
在1974年至1979年期间由儿科药物监测项目监测的3587名住院儿童中，32%的儿童开具了对乙酰氨基酚处方，3%的儿童开具了阿司匹林处方。在入院前的三个月里，23%的儿童报告使用了这两种药物中的任何一种。在住院和入院前的情况下，对乙酰氨基酚的使用在1975年至1977年期间有所增加，随后减少。阿司匹林的处方在整个研究期间住院患者中保持一致，但入院前的使用大幅下降。马萨诸塞州中毒信息中心观察到，1976年至1977年以及1977年至1978年期间，关于阿司匹林的咨询电话增加了36%，与所有咨询电话的增加情况相似，但对乙酰氨基酚的咨询电话增加了87%。长期以来对阿司匹林毒性作用的担忧，以及最近对过量服用对乙酰氨基酚肝毒性作用的担忧，可能导致医生和家长减少这两种药物用于治疗发热的使用。
