铝相关性骨病：临床病理相关性

Aluminum associated bone disease: clinico-pathologic correlation.

作者信息

Ihle B, Buchanan M, Stevens B, Marshal A, Plomley R, d'Apice A, Kincaid-Smith P

出版信息

Am J Kidney Dis. 1982 Sep;2(2):255-63. doi: 10.1016/s0272-6386(82)80071-1.

Abstract

A chemical, aurine tricarboxylic acid was used to identify aluminum in bone in a group of chronic renal failure patients with severe osteomalacia. Thirteen out of 49 (26%) patients had a positive stain at the bone-osteoid junction. The presence of aluminum at the staining site was confirmed by electron dispersion x-ray analysis. The patients' biopsies staining negative with this clinical, although having high bone aluminum levels, had more significant features of hyperparathyroidism, both biochemically and histologically than those having a positive stain. The usefulness of this technique to diagnose presymptomatic aluminum related osteomalacia is emphasized.

摘要

一种名为金精三羧酸的化学物质被用于在一组患有严重骨软化症的慢性肾衰竭患者的骨骼中鉴定铝。49名患者中有13名（26%）在骨类骨质交界处染色呈阳性。通过电子色散X射线分析证实了染色部位存在铝。尽管这些患者活检时该临床染色呈阴性，但骨铝水平较高，与染色呈阳性的患者相比，在生化和组织学上具有更显著的甲状旁腺功能亢进特征。强调了该技术在诊断无症状性铝相关性骨软化症方面的实用性。