Incze J, Vaughan C W, Lui P, Strong M S, Kulapaditharom B
Am J Surg. 1982 Oct;144(4):401-5. doi: 10.1016/0002-9610(82)90411-1.
Biopsy specimens of "normal" mucous membrane of patients susceptible to the effects of the carcinogens of tobacco revealed morphologic abnormalities on electron microscopic examination that were consistent with the concept that carcinogenesis is a multistep process of sequential neoplastic development extending over a long period of time. Such changes in the upper aerodigestive tract are probably tobacco induced and may be reversible if tobacco exposure is eliminated. Use of the electron microscope can provide the clinician with an accurate assay of the severity of mucosal alterations induced by tobacco. The ability to detect such morphologic abnormalities should provide another deterrant to smoking and a useful tool in the further study of these phenomena.
对易受烟草致癌物影响的患者的“正常”黏膜活检标本进行电子显微镜检查时，发现了形态学异常，这与致癌作用是一个长期的、连续的肿瘤性发展的多步骤过程这一概念相符。上呼吸道消化道的此类变化可能是由烟草引起的，如果消除烟草暴露，可能是可逆的。电子显微镜的使用可为临床医生提供对烟草引起的黏膜改变严重程度的准确测定。检测到这种形态学异常的能力应为戒烟提供另一种威慑，并成为进一步研究这些现象的有用工具。
